The Oxford Biblical Studies Online and Oxford Islamic Studies Online have retired. Content you previously purchased on Oxford Biblical Studies Online or Oxford Islamic Studies Online has now moved to Oxford Reference, Oxford Handbooks Online, Oxford Scholarship Online, or What Everyone Needs to Know®. For information on how to continue to view articles visit the subscriber services page.

Related Content

More Like This

Show all results sharing this subject:

  • Medicine and health


Show Summary Details


Tay-Sachs disease

Quick Reference

(amaurotic familial idiocy) an inherited disorder of lipid metabolism (see lipidosis) in which abnormal accumulation of lipid in the brain leads to blindness, mental retardation, and death in infancy. The gene responsible for the disorder is recessive, and the disease can now be largely prevented by genetic counselling in communities known to be affected (primarily Ashkenazi Jewish communities). W. Tay (1843–1927), British physician; B. Sachs (1858–1944), US neurologist

Reference entries

View all reference entries »