Show Summary Details
Overview
SUFU
Quick Reference
The major negative regulator of the sonic hedgehog/*patched signalling pathway in vertebrates (suppressor of fused). The human gene has 40% homology with the Drosophila gene and the product (484 aa) inhibits the transcriptional activity of gli-1 (glioma-associated oncogene-1) and osteogenic differentiation in response to sonic hedgehog signalling.
From: SUFU in A Dictionary of Biomedicine »
Subjects: Medicine and health
