The Oxford Biblical Studies Online and Oxford Islamic Studies Online have retired. Content you previously purchased on Oxford Biblical Studies Online or Oxford Islamic Studies Online has now moved to Oxford Reference, Oxford Handbooks Online, Oxford Scholarship Online, or What Everyone Needs to Know®. For information on how to continue to view articles visit the subscriber services page.

Related Content

More Like This

Show all results sharing these subjects:

  • Science and technology
  • Chemistry


Show Summary Details



Quick Reference

A set of small Trp-free, multifunctional glycoproteins (co-β-glucosidase, A1 activator, glucosylceramidase activator, SAP-A–D, 81 aa) derived from a single precursor, prosaposin, that act as sphingolipid activator proteins (SAPs) and assist in the lysosomal hydrolysis of sphingolipids.Other functions include neuritogenic/neuroprotection effects and induction of membrane fusion. Deficiency of saposin A causes atypical Krabbe's disease, deficiency of saposin B causes metachromatic leukodystrophy, deficiency of saposin C causes an atypical form of Gaucher's disease. Saposin-like proteins (SAPLIPs) include surfactant protein B (SP-B), Entamoeba histolytica pore-forming peptide, granulysin, NK-lysin, acid sphingomyelinase, and acyloxyacyl hydrolase.

Reference entries