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Frat proteins

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Products of the human homologues of the murine proto-oncogene (frequently rearranged in advanced T-cell lymphomas), originally identified in transplanted tumours of Moloney murine leukaemia virus (M-MuLV)-infected Emu-Pim1 transgenic mice. Together with GBP (glycogen synthase kinase (GSK3)-binding protein), Frat-1 and Frat-2 constitute a family of GSK3-binding proteins that inhibit the phosphorylation of β-*catenin, preventing its degradation by the ubiquitin-proteasome pathway, thus potentially playing a role in Wnt signal transduction. A Frat-null mouse is, however, viable.

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