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n. an increase in the number of prickle cells in the innermost layer of the epidermis, leading to thickening of the epidermis. Acanthosis nigricans is associated with insulin resistance; it is characterized by papillomatous growths, mainly in the armpits, giving the skin a pigmented appearance and a velvety texture. It may be benign or malignant. Pseudoacanthosis nigricans is more common and is associated with obesity and insulin resistance.

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