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date: 08 March 2021

Crossover Clinical Trial, Crossover Experiment 

A Dictionary of Epidemiology

Miquel Porta

A method of comparing two (or more) treatments or interventions in which subjects, upon completion of one treatment, are switched to the other. In the case of two treatments, A and B, half the patients are randomly allocated to receive these in the order “A first, then B,” and half to receive them in the order “B first, then A.” The outcomes cannot be permanent changes (e.g., they can be symptoms, functional capacity). A “washout” phase is often needed before beginning the second treatment. The analysis will have to check whether a ... ...

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