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polyposis

n. a condition in which numerous polyps form in an organ or tissue. Familial adenomatous polyposis (FAP) is a hereditary disease (caused by a defective dominant gene) in which ...

polyposis

polyposis n.   Quick reference

Concise Medical Dictionary (10 ed.)

Reference type:
Subject Reference
Current Version:
2020
Subject:
Medicine and health, Clinical Medicine
Length:
79 words

... n. a condition in which numerous polyps form in an organ or tissue. Familial adenomatous polyposis ( FAP ) is a hereditary disease (caused by a defective dominant gene) in which multiple adenomas develop in the intestine, usually the large bowel or rectum, at an early age. As these polyps almost invariably become malignant, patients are usually advised to undergo total removal of the affected bowel. See also Peutz-Jeghers syndrome . Compare hereditary nonpolyposis colorectal cancer ; pseudopolyposis...

polyposis

polyposis n.   Quick reference

A Dictionary of Nursing (7 ed.)

Reference type:
Subject Reference
Current Version:
2017
Subject:
Medicine and health
Length:
70 words

...polyposis [poli- poh -sis] n. a condition in which numerous polyps form in an organ or tissue. familial adenomatous p. ( p. coli ) a hereditary disease in which multiple adenomas develop in the gastrointestinal tract, usually the colon or rectum, at an early age. As these polyps almost invariably become malignant, patients are usually advised to undergo total removal of the affected bowel. See also Peutz-Jeghers syndrome . Compare pseudopolyposis ....

polyposis coli

polyposis coli   Quick reference

A Dictionary of Biomedicine (2 ed.)

Reference type:
Subject Reference
Current Version:
2019

...polyposis coli An autosomal dominant disorder (adenomatous polyposis coli, familial adenomatous polyposis, FAP) in which there is a predisposition to cancer. Affected individuals develop hundreds to thousands of adenomatous polyps of the colon and rectum which may progress to malignancy. The mutated gene ( APC gene) encodes a multidomain tumour suppressor that antagonizes the wnt signalling pathway and is implicated in other carcinomas. Gardner’s syndrome is a variant of FAP, caused by mutation in the same gene, in which a variety of other tumours...

juvenile polyposis

juvenile polyposis   Quick reference

A Dictionary of Biomedicine (2 ed.)

Reference type:
Subject Reference
Current Version:
2019

...juvenile polyposis An autosomal dominant condition that predisposes to various types of tumours and can be caused by mutations in the SMAD4 gene or in the gene encoding bone morphogenetic protein receptor-1A ( ALK3 ). There are hamartomatous gastrointestinal polyps that turn into malignant lesions in ~20% of cases....

familial adenomatous polyposis

familial adenomatous polyposis   Quick reference

A Dictionary of Dentistry (2 ed.)

Reference type:
Subject Reference
Current Version:
2020
Subject:
Medicine and health, Dentistry
Length:
92 words

...familial adenomatous polyposis ( FAP ) An inherited autosomal dominant disorder characterized by many thousands of glandular tissue polyps throughout the colorectal part of the digestive tract. There is a very high risk of developing colorectal carcinoma if patients are not treated with colectomy. Bone lesions of the mandible and maxilla and dental abnormalities such as impacted teeth other than third molars, supernumerary teeth , congenitally missing teeth, and fused roots are present in more than 70% of individuals. It is also known as Gardner’s...

polyposis

polyposis noun   Quick reference

New Oxford American Dictionary (3 ed.)

Reference type:
English Dictionary
Current Version:
2015
Subject:
English Dictionaries and Thesauri
Length:
50 words
polyposis

polyposis noun   Quick reference

Oxford Dictionary of English (3 ed.)

Reference type:
English Dictionary
Current Version:
2015
Subject:
English Dictionaries and Thesauri
Length:
54 words
polyposis

polyposis noun   Reference library

Australian Oxford Dictionary (2 ed.)

Reference type:
English Dictionary
Current Version:
2004
Subject:
English Dictionaries and Thesauri
Length:
36 words
polyposis

polyposis  

Reference type:
Overview Page
n. a condition in which numerous polyps form in an organ or tissue. Familial adenomatous polyposis (FAP) is a hereditary disease (caused by a defective dominant gene) in which multiple adenomas ...
juvenile polyposis

juvenile polyposis  

Reference type:
Overview Page
An autosomal dominant condition that predisposes to various types of tumours and can be caused by mutations in the SMAD4 gene or in the gene encoding bone morphogenetic protein receptor-1A (ALK3). ...
tubulovillous adenoma

tubulovillous adenoma  

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Overview Page
A type of polyp that arises in the colon and rectum and can undergo malignant transformation, usually over a period of years, although this can occur more rapidly in familial polyposis syndromes.
EB1

EB1  

Reference type:
Overview Page
A member of the RP/EB family of proteins (adenomatous polyposis coli-binding protein EB1, microtubule-associated protein, RP/EB family member 1, MAPRE1, 268 aa) that was isolated in a two-hybrid ...
gastric cancer

gastric cancer  

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Overview Page
Carcinoma of the stomach, probably the second most common carcinoma. Several genes may be associated with an increased risk of gastric cancer and there are various inherited cancer predisposition ...
APC

APC  

The human gene for adenomatous polyposis coli protein. The gene is a tumour suppressor, and mutations are associated with familial adenomatous polyposis, Gardner's syndrome, etc. and contribute to ...
adenosquamous

adenosquamous  

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Overview Page
Describing a benign tumour of epithelial origin (an adenoma) in which cells have flattened (squamous) morphology, rather than being cuboidal or columnar.
desmoid tumour

desmoid tumour  

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Overview Page
A dense connective-tissue tumour with a dangerous propensity for repeated local recurrence after treatment. Intra-abdominal desmoids have an association with familial adenomatous polyposis (FAP).
tumour suppressor

tumour suppressor  

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Overview Page
Generally a gene (antioncogene, cancer susceptibility gene) encoding a negative regulator of the cell cycle, e.g. an inhibitor of a growth factor signalling system, that must be mutated or otherwise ...
Peutz–Jeghers syndrome

Peutz–Jeghers syndrome  

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Overview Page
A hereditary disorder in which the presence of multiple polyps in the lining of the small intestine (intestinal polyposis) is associated with pigmented areas (similar to freckles) around the lips, on ...
hereditary nonpolyposis colorectal cancer

hereditary nonpolyposis colorectal cancer  

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Overview Page
(HNPCC, Lynch syndrome) an inherited disorder in which there is an increased incidence of colorectal polyp formation, although to a lesser extent than in familial adenomatous polyposis (FAP). HNPCC ...
Gardner's syndrome

Gardner's syndrome  

Reference type:
Overview Page
A variant form of familial adenomatous polyposis in which polyps in the colon are associated with fibromas and osteomas (benign tumours), especially of the skull and jaw, and multiple sebaceous ...

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