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homeotic gene Quick reference
A Dictionary of Zoology (5 ed.)
... gene ( homoeotic gene , Hox gene ) A homeobox gene in which mutations can transform part or whole of a body segment into the corresponding part of another segment. Homeotic genes are involved in the development of the basic body plan of metamerically segmented animals...
homeotic gene Reference library
Oxford Dictionary of Biochemistry and Molecular Biology (2 ed.)
... gene or homeodomain‐encoding gene or homeobox‐encoding gene or Hox gene any of the genes that are allelic for mutations resulting in the conversion of one body part into another. Homeotic genes were first discovered in Drosophila ; a mutation in such a gene could, e.g., result in a leg replacing an antenna. While Drosophila has only two Hox clusters, in nematodes there is one, and in vertebrates four clusters of 9 to 11 genes each located on a separate chromosome and spanning more than 100 kb. The vertebrate Hox genes are expressed in...
homeotic gene
homeotic genes Quick reference
A Dictionary of Biomedicine (2 ed.)
...developmental abnormalities ( homeotic mutants ). Homeobox genes are clustered and activated in a 3′ to 5′ direction with genes that are involved in morphologically anterior systems, which are activated earlier in development, at the 3′ end. This colinearity of genes and morphological position is intriguing. Vertebrates have four duplicate sets (paralogues) of the ten ancient homeotic genes, known as Hoxa, Hoxb, Hoxc , and Hoxd . Synpolydactyly is one of relatively few developmental defects caused by mutations in hox genes...
homeotic genes Quick reference
A Dictionary of Biology (8 ed.)
...homeotic genes A class of genes, including the Hox genes, that play a central role in controlling the early development and differentiation of embryonic tissues in eukaryotic organisms, including plants, animals, and fungi. They code for transcription factors —proteins that bind to DNA and regulate the expression of a wide range of other genes. This binding capability resides in a structural domain of the protein called a homeodomain, encoded by a nucleotide sequence that is characteristic of homeotic genes ( see homeobox ). These genes were first...
homeotic mutations
homeotic selector
Edward B. Lewis
floral organ identity mutations
bithorax
proboscipedia
Hox genes
BX-C
segment identity genes
antennapedia
spineless-aristapedia
body plan
MADS box gene
polycomb repressive complexes
