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Overview

dermatofibrosarcoma protuberans

A tumour probably derived from histiocytes that may occur in any part of the body. It is locally invasive but tends not to metastasize. It often recurs locally despite excision.

dermatofibrosarcoma protuberans

dermatofibrosarcoma protuberans   Quick reference

Concise Medical Dictionary (10 ed.)

Reference type:
Subject Reference
Current Version:
2020
Subject:
Medicine and health, Clinical Medicine
Length:
33 words

... protuberans a tumour probably derived from histiocytes that may occur in any part of the body. It is locally invasive but tends not to metastasize. It often recurs locally despite...

dermatofibrosarcoma protuberans

dermatofibrosarcoma protuberans   Quick reference

A Dictionary of Biomedicine (2 ed.)

Reference type:
Subject Reference
Current Version:
2019

...dermatofibrosarcoma protuberans A rare infiltrative skin tumour of intermediate malignancy in which there is unregulated PDGF production as a result of a chromosomal translocation that generates a collagen-1/PDGF-B fusion protein that is processed to generate mitogenically-active PDGF-B....

Dermatofibrosarcoma protuberans

Dermatofibrosarcoma protuberans   Reference library

A-Z of Plastic Surgery

Reference type:
Subject Reference
Current Version:
2009
Subject:
Medicine and health, Surgery
Length:
119 words

... protuberans • Considered a malignant form of fibrohistiocytic tumour, though metastasis is virtually unknown. Tendency to local recurrence. • Usually arises in the dermis of the trunk and proximal extremities. • More common in men. Peak incidence in the 30s. • Presents as a firm plaque-like bluish-red nodule with a keloid-like appearance. • May remain unchanged for years and then develop a rapid growth phase to form a multinodular mass. • Histologically, there is a characteristic ‘cartwheel’ pattern of fibrous bundles in a...

dermatofibrosarcoma protuberans

dermatofibrosarcoma protuberans  

Reference type:
Overview Page
A tumour probably derived from histiocytes that may occur in any part of the body. It is locally invasive but tends not to metastasize. It often recurs locally despite excision.
Abdominal wall reconstruction

Abdominal wall reconstruction  

Reference type:
Overview Page
Indications:• Trauma.• Tumour: Desmoid, Dermatofibrosarcoma protuberans.• Radiation.• Infection: Gas gangrene, Necrotizing fasciitis.• Iatrogenic: Incisional hernia.• Congenital: Omphalocoele, ...
dermatological disorders

dermatological disorders  

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Overview Page
The skin is a complex tissue that serves as a barrier to fluid loss and to the entry of pathogenic organisms; it must be flexible but nevertheless withstand mechanical stress and abrasion. The ...
PDGF

PDGF  

Platelet-derived growth factor (see growth factor).
sarcoma

sarcoma  

Reference type:
Overview Page
A malignant tumour derived from connective tissue cells, e.g. osteosarcoma (from bone). Some sarcomas are of viral origin: see Rous sarcoma virus; S180; src gene.
collagen

collagen  

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Overview Page
n. a protein that is the principal constituent of white fibrous connective tissue (as occurs in tendons). Collagen is also found in skin, bone, cartilage, and ligaments. It is relatively inelastic ...
Fibrous tumours

Fibrous tumours   Reference library

A-Z of Plastic Surgery

Reference type:
Subject Reference
Current Version:
2009
Subject:
Medicine and health, Surgery
Length:
12 words

...tumours • Dermatofibroma . • Pseudosarcomatous lesions . • Dermatofibrosarcoma protuberans . • Angiofibroma...

Mesodermal tumours

Mesodermal tumours   Reference library

A-Z of Plastic Surgery

Reference type:
Subject Reference
Current Version:
2009
Subject:
Medicine and health, Surgery
Length:
15 words

...tumours • Acrochordon . • Dermatofibroma . • Dermatofibrosarcoma protuberans . • Neurofibroma . • Granula cell tumour...

PDGF

PDGF   Quick reference

A Dictionary of Biomedicine (2 ed.)

Reference type:
Subject Reference
Current Version:
2019

...homologous and exist in various isoforms. The PDGF receptor is a tyrosine kinase (~1100 aa) that signals through the PI-3-kinase cascade. A fusion between intron 43 of the type I collagen gene and intron 1 of the platelet-derived growth factor β ‎ gene results in dermatofibrosarcoma protuberans through ectopic overproduction of...

Moh’s surgery

Moh’s surgery   Reference library

A-Z of Plastic Surgery

Reference type:
Subject Reference
Current Version:
2009
Subject:
Medicine and health, Surgery
Length:
172 words

...frozen-section technique to immediately examine the microscopic margins. Immediate feedback is given about positive margins which are then re-excised until clear. • Useful for infiltrative BCCs, verrucous carcinoma of the mouth, genitalia or feet, keratoacanthomas, dermatofibrosarcoma protuberans, malignant fibrous histiocytoma, atypical fibroxanthoma, extramammary Paget’s, sebaceous carcinomas which often affect the eyelid, adenoid cystic carcinoma and granular cell tumours. • The cure rate is 99% for BCCs and 95% for SCCs. Procedure: • Usually LA. First...

Abdominal wall reconstruction

Abdominal wall reconstruction   Reference library

A-Z of Plastic Surgery

Reference type:
Subject Reference
Current Version:
2009
Subject:
Medicine and health, Surgery
Length:
169 words

...wall reconstruction Indications: • Trauma . • Tumour: Desmoid , Dermatofibrosarcoma protuberans . • Radiation . • Infection: Gas gangrene , Necrotizing fasciitis . • Iatrogenic: Incisional hernia . • Congenital: Omphalocoele , Gastroshisis , Prune belly syndrome . Management of acute loss: After aggressive debridement, avoid closure under tension and avoid raising flaps acutely. Cover viscera with synthetic mesh. Objectives: Cover abdominal contents, prevent herniation and restore the appearance. When direct closure is not...

dermatological disorders

dermatological disorders   Quick reference

A Dictionary of Biomedicine (2 ed.)

Reference type:
Subject Reference
Current Version:
2019

...; eczema ; psoriasis ); in others the defects are in cellular components such as desmosomes that are important for mechanical resistance ( see ectodermal dysplasia ; epidermolysis bullosa ; Hailey–Hailey disease ; pemphigus ). See also acanthoma ; dermatofibrosarcoma protuberans ; dermatographia ; dermatomyositis ; dermatophytes ; familial primary localized cutaneous amyloidosis ; hyperkeratosis ; ichthyosiform erythroderma ; ichthyosis ; keratoacanthoma ; lichen planus ; Merkel cell carcinoma ; Molluscum contagiosum virus ; ...

Sarcoma

Sarcoma   Reference library

A-Z of Plastic Surgery

Reference type:
Subject Reference
Current Version:
2009
Subject:
Medicine and health, Surgery
Length:
520 words

...muscle: Rhabdomyosarcoma ; ○ fat: liposarcoma; ○ blood vessels: Angiosarcoma , Kaposi’s sarcoma; ○ lymph channels: lymphangiosarcoma; ○ fibrous tissue: fibrosarcoma; ○ nerve: malignant Schwannoma; ○ synovial tissue: synovial sarcoma; ○ skin: Dermatofibrosarcoma protuberans , Atypical fibroxanthoma , Malignant fibrous histiocytoma . • TNMG classification: ○ T1: tumours <5 cm; ○ T2: tumours >5 cm; ○ T3: invading bone, vessel, nerve; ○ N0: no nodes; ○ N1: nodes; ○ M0: no metastase s ; ○ M1: distant metastases; ○ ...

collagen

collagen   Quick reference

A Dictionary of Biomedicine (2 ed.)

Reference type:
Subject Reference
Current Version:
2019

...hydroxyapatite. Defects in collagen α ‎1(I) are the cause of Caffey’s disease , some forms of Ehlers–Danlos syndrome , and osteogenesis imperfecta . Variations are associated with involutional osteoporosis , and a chromosomal translocation of the gene causes dermatofibrosarcoma protuberans . Collagen type II (COL2A1, 1487 aa) is a homotrimer of α ‎1(II) collagen (chondrocalcin) specific for cartilaginous tissues; defects are the cause of a variety of chondrodysplasias, including hypochondrogenesis and osteoarthritis . Defects are also responsible...

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