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Overview

catenins

Proteins that are associated with the cytoplasmic domain of adhesion molecules such as cadherins and link them to the cytoskeleton. A second role is in regulating transcription factors. ...

catenins

catenins   Quick reference

A Dictionary of Genetics (8 ed.)

Reference type:
Subject Reference
Current Version:
2014
Subject:
Science and technology, Life Sciences
Length:
90 words

... a family of intracellular proteins that are a component of the junctional complexes which mediate adhesion between cells and signal contact inhibition ( q.v .). In humans, alpha and beta catenins are encoded by genes at 5q31 and 3p22, respectively. The sequences of the two genes show no similarity. The alpha and beta proteins form 1:1 heterodimers, and they attach the inward-reaching carboxyl ends of molecules of cadherins ( q.v .) to actin ( q.v .) filaments within the cell. In Xenopus , beta catenins provide the first signal of dorsal ventral polarity...

catenins

catenins   Quick reference

A Dictionary of Biomedicine (2 ed.)

Reference type:
Subject Reference
Current Version:
2019

...catenins Proteins that are associated with the cytoplasmic domain of adhesion molecules such as cadherins and link them to the cytoskeleton. A second role is in regulating transcription factors. α ‎-Catenin (906 aa) is a vinculin -related protein involved in adherens junction-mediated intercellular adhesion; abnormalities are associated with cancer invasion and metastasis. β ‎-Catenin (781 aa) binds E-cadherin and N-cadherin. A second pool of β ‎-catenin is cytoplasmic and coimmunoprecipitates with the adenomatous polyposis coli ( APC ) tumour...

catenins

catenins  

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Overview Page
Proteins that are associated with the cytoplasmic domain of adhesion molecules such as cadherins and link them to the cytoskeleton. A second role is in regulating transcription factors. α-Catenin ...
catenin

catenin   Reference library

Oxford Dictionary of Biochemistry and Molecular Biology (2 ed.)

Reference type:
Subject Reference
Current Version:
2008
Subject:
Science and technology, Life Sciences
Length:
159 words

... any of four intracellular attachment proteins of the armadillo family, designated α, β, γ, and δ. They bind actin microfilaments to the cytoplasmic domain of E‐cadlierin at adherens junctions of epithelial cells. αCatenin (906 amino acids) is homologous with vinculin . β‐Catenin (781 amino acids) is enriched in adherens junctions in cells lining the mammalian cerebral ventricles; it is homologous with γ‐catenin ( or plakoglobin ). δ‐Catenin is expressed in neurons, where it associates with presenilins. APC protein ( see APC ) plays an...

catenin

catenin   Quick reference

A Dictionary of Biology (8 ed.)

Reference type:
Subject Reference
Current Version:
2019
Subject:
Science and technology, Life Sciences
Length:
142 words

...catenin Any of a family of proteins that act with other cell adhesion molecules to bind cells together. Catenins anchor the actin filaments of the internal cytoskeleton to the cadherin molecules that span the space between adjacent cells at adherens junctions and (in the case of β ‎-catenin) at desmosomes . Together these components maintain the three-dimensional structure and function of cell layers. They are also important in determining cell fate and organization during development. Moreover, β ‎-catenin functions with WNT protein in a signal...

armadillo repeat

armadillo repeat  

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A protein–protein interaction motif (42 aa), originally described in the Drosophila β-catenin family protein armadillo. The armadillo repeat-containing proteins can be divided into subfamilies based ...
dapper

dapper  

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An antagonist of β-*catenin (frodo, 836 aa) that inhibits activation of JNK by dishevelled. Dapper-2 (774 aa) has a different tissue distribution.
PAPIN

PAPIN  

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A protein (plakophilin-related armadillo-repeat protein-interacting protein, activated in prostate cancer, AIPC, 2642 aa) with six PDZ domains that is highly expressed in prostate cancer. It ...
Disheveled

Disheveled  

A transduction component of Wnt/Frizzled signalling, that protects β‐catenin against phosphorylation and degradation via ubiquitination and proteasomes. See catenin.
aardvark

aardvark  

A Dictyostelium orthologue of β‐catenin with cytoskeletal and signal transduction roles. See catenin.
armadillo

armadillo  

Any of a family of proteins that includes β‐catenin, which forms a multimeric complex with presenilins. These proteins contain an imperfect repeat of ≈42 residues, which forms three alpha helices. ...
spondin

spondin  

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Proteins involved in patterning axonal growth by inhibiting or promoting adhesion of embryonic nerve cells. Spondin 1 (F-spondin, 624 aa) is a secreted extracellular matrix protein that interacts ...
T-cell factor

T-cell factor  

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(TCF)A family of transcription factors (lymphoid enhancer-binding factor (LEF), LEF/TCFs) that are important in the wnt/β-*catenin signalling cascade. The nomenclature is very confusing: TCF1 (T-cell ...
eplin

eplin  

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A LIM domain protein (epithelial protein lost in neoplasm, Lima-1) that mediates linkage of the cadherin–catenin complex to F-actin and is important in assembly and stability of the adherens ...
arrhythmogenic right ventricular dysplasia/cardiomyopathy

arrhythmogenic right ventricular dysplasia/cardiomyopathy  

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(ARVD/ARVC)A range of autosomal dominant disorders in which there is arrhythmia of the right ventricle of the heart and replacement of muscle with fibrous tissue; they are an inherited cause of ...
Frat proteins

Frat proteins  

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Products of the human homologues of the murine proto-oncogene (frequently rearranged in advanced T-cell lymphomas), originally identified in transplanted tumours of Moloney murine leukaemia virus ...
nectin

nectin  

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1. A protein component of the stalk of mitochondrial ATPase.2. An immunoglobulin-like cell adhesion molecule that is calcium-independent and causes adhesion by interaction with other nectin ...
pilomatrixoma

pilomatrixoma  

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A firm, circumscribed tumour (epithelioma calcificans of Malherbe), usually in the head and neck area, which feels like a button. Caused in some cases by mutation in the β-*catenin gene.
p0071

p0071  

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A protein (plakophilin-4, 1211 aa) of the catenin/*plakophilin family that has ten armadillo repeats. It is mostly localized in epithelial cells at regions of cell–cell contact and may colocalize ...
IQGAPs

IQGAPs  

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Multidomain scaffold proteins (IQ motif-containing GTPase activating proteins, p195, IQGAP1, 1657 aa; IQGAP2, 1575 aa) that bind to a wide variety of targets, including actin, catenin, rho family ...

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