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Wnt

The symbol for a group of homologous genes which encode proteins that regulate cell-to-cell interactions during development. The Drosophila gene wingless (wg) controls the segmental ...

Wnt

Wnt   Quick reference

A Dictionary of Genetics (8 ed.)

Reference type:
Subject Reference
Current Version:
2014
Subject:
Science and technology, Life Sciences
Length:
163 words

... the symbol for a group of homologous genes which encode proteins that regulate cell-to-cell interactions during development. The Drosophila gene wingless ( wg ) controls the segmental pattern of the embryo, and the mouse was later shown to have a homologous gene called integration ( int ). Once it became clear that these genes were conserved in both invertebrates and vertebrates, the symbol Wnt was chosen, w from wg and nt from int , to reflect the widespread evolutionary distribution of this family. The proteins encoded by Wnt genes are...

Wnt

Wnt   Reference library

Oxford Dictionary of Biochemistry and Molecular Biology (2 ed.)

Reference type:
Subject Reference
Current Version:
2008
Subject:
Science and technology, Life Sciences
Length:
90 words

... abbr. for ( Drosophila ) Wingless/Int‐1; any of a family of secreted signalling glycoproteins found throughout the animal kingdom. They are important for patterning and development in the embryo and for regulation of cell proliferation thereafter. Wnt‐1 is expressed in the central nervous system. On binding to G‐protein‐coupled receptors of the Frizzled family in the plasma membrane, they cause inactivation of GSK‐3 , which is complexed with APC protein, axin, and β‐catenin, and targeted for ubiquitination and proteosomal degradation. In the...

wnt

wnt   Quick reference

A Dictionary of Biomedicine (2 ed.)

Reference type:
Subject Reference
Current Version:
2019

...wnt A family of genes that encode secreted glycoproteins involved in various developmental processes, particularly specification of position and morphogenetic events, but also in carcinogenesis. The original example was the Drosophila gene wingless , but many vertebrate homologues have subsequently been discovered (there are at least ten) and a complex signalling system worked out. The w nt-1 (formerly int-1, see int oncogenes ) product binds to cell-surface receptors of the Frizzled family, causing the receptors to activate Dishevelled family proteins...

WNT family

WNT family   Reference library

Oxford Dictionary of Biochemistry and Molecular Biology (2 ed.)

Reference type:
Subject Reference
Current Version:
2008
Subject:
Science and technology, Life Sciences
Length:
44 words

... family a family of secreted glycoproteins (e.g. WNT‐2 from human and mouse) that are signalling molecules in tissue development. They act through G‐protein‐associated membrane receptors of the frizzled family to inhibit glycogen synthase kinase 3. The WNT‐1 gene is closely homologous to wingless...

WNT protein

WNT protein   Quick reference

A Dictionary of Biology (8 ed.)

Reference type:
Subject Reference
Current Version:
2019
Subject:
Science and technology, Life Sciences
Length:
200 words

...) in the cytosol. This migrates to the nucleus, where it interacts with the transcription factor TCF (T-cell factor) to activate transcription of target genes. The homologous gene in mammals, Wnt1 , acts through a similar pathway. WNT1 protein binds to receptors of the Frizzled family and is involved in development of the central nervous system. Other members of the WNT family have roles in the patterning of various...

Wnt inhibitory factor 1

Wnt inhibitory factor 1   Reference library

Oxford Dictionary of Biochemistry and Molecular Biology (2 ed.)

Reference type:
Subject Reference
Current Version:
2008
Subject:
Science and technology, Life Sciences
Length:
57 words

... inhibitory factor 1 1 abbr. : WIF‐1; a secreted protein that contains an N‐terminal WIF domain (≈150 amino acids), which binds and inhibits Wnt proteins; five EGF‐like repeats; and a short hydrophilic domain in the C‐terminal region. Homologues are present in many animals. The WIF domain is related to the extracellular domain of Ryk receptor tyrosine...

WNT

WNT [Airline]   Quick reference

A Dictionary of Abbreviations

Reference type:
Subject Reference
Current Version:
2011
Subject:
Encyclopedias, Language reference
Length:
7 words

... [Airline] Winnport Logistics, Inc. =...

Wnt

Wnt  

The symbol for a group of homologous genes which encode proteins that regulate cell-to-cell interactions during development. The Drosophila gene wingless (wg) controls the segmental pattern of the ...
WNT protein

WNT protein  

Any of a family of proteins that are involved in signal transduction pathways crucial in regulating cell proliferation, differentiation, and survival, both during embryological development and in ...
Wnt inhibitory factor 1

Wnt inhibitory factor 1  

1 abbr.: WIF‐1; a secreted protein that contains an N‐terminal WIF domain (≈150 amino acids), which binds and inhibits Wnt proteins; five EGF‐like repeats; and a short hydrophilic domain in ...
WISP

WISP  

Reference type:
Overview Page
Regulatory proteins (Wnt-induced secreted proteins) of the CCN family of regulatory proteins expressed downstream of wnt and involved in morphological transformation. WISP-1 (367 aa), WISP-2 (250 ...
int oncogenes

int oncogenes  

Reference type:
Overview Page
Oncogenes first identified as genes activated by integration of mouse mammary tumour virus and causing the development of carcinomas. The nomenclature is therefore misleading: they are simply genes ...
canonical

canonical  

Reference type:
Overview Page
Describing something classical, archetypal, or prototypic, often applied to a sequence of nucleotides or amino acids that reflects the most common choice of base or amino acid at each position. A ...
dickkopf

dickkopf  

Reference type:
Overview Page
A family of secreted proteins (220–350 aa) that are inhibitors of Wnt signalling. Originally identified in Xenopus but human homologues (DKK1–4) have subsequently been identified. There is a ...
dishevelled-1

dishevelled-1  

Reference type:
Overview Page
The homologue of the product of the Drosophila gene dishevelled, a scaffold phosphoprotein that regulates cell proliferation, and that is involved in the Wnt signalling system. Interacts with MuSK in ...
lentoid

lentoid  

Reference type:
Overview Page
1. Lens-shaped or lens-like.2. Lentoid bodies may form in vitro through aggregation of lens epithelial cells to form a spherical mass with a central core of lens-like cells containing crystallins. ...
frizzled

frizzled  

Reference type:
Overview Page
A family of ten G-protein-coupled receptors involved in the wnt signalling pathway and other signalling pathways. Ligand binding induces activation of dishevelled proteins in the cytoplasm and ...
ryk

ryk  

An atypical receptor protein tyrosine kinase that functions as a coreceptor along with Frizzled for Wnt ligands and binds to dishevelled, through which it activates the canonical Wnt pathway.
WIF-1

WIF-1  

abbr. for Wnt‐inhibitory factor‐1. See Wnt.
casein kinases

casein kinases  

A group of kinases that preferentially phosphorylate acidic proteins such as caseins but can phosphorylate a large number of proteins. Casein kinase 1 (EC 2.7.11.1, multiple isoforms, ~415 aa) ...

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