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Overview

STE20 kinases

A group of serine/threonine kinases involved in regulating a range of processes including the cell cycle, apoptosis, and stress responses. Yeast Ste20p (sterile 20 protein) is a ...

STE20 kinases

STE20 kinases   Quick reference

A Dictionary of Biomedicine (2 ed.)

Reference type:
Subject Reference
Current Version:
2019

...STE20 kinases A group of serine/threonine kinases involved in regulating a range of processes including the cell cycle, apoptosis, and stress responses. Yeast Ste20p (sterile 20 protein) is a mitogen-activated protein kinase kinase kinase kinase (MAP4K) involved in the mating pathway. The human homologues, of which there are 28, have a conserved kinase domain but a diversity of additional domains involved in interactions with signalling systems and cytoskeletal-regulatory proteins. The Ste20 group kinases are further divided into the p21-activated kinase (...

STE20 kinases

STE20 kinases  

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Overview Page
A group of serine/threonine kinases involved in regulating a range of processes including the cell cycle, apoptosis, and stress responses. Yeast Ste20p (sterile 20 protein) is a mitogen-activated ...
germinal centre

germinal centre  

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Morphologically distinct regions that develop within lymphoid organs following activation of B cells. They contain large numbers of antigen presenting cells (follicular dendritic cells) as well as ...
SLK

SLK  

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A microtubule-associated STE20-like kinase (1235 aa, of the germinal centre subfamily of STE20-like kinases) that is required for focal adhesion turnover and cell migration downstream of the ...
SPAK

SPAK  

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A serine/threonine kinase (Ste20/SPS-1-related proline, alanine-rich kinase, 547 aa) that will phosphorylate and activate NKCC1 (Na+-K+-2Cl− cotransporter-1). SPAK and OSR1 (oxidative ...
SOK1

SOK1  

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A Ste20 protein kinase of the germinal centre kinase (GCK) family that is activated by oxidant stress and chemical anoxia, a cell culture model of ischaemia. It is localized in the Golgi apparatus, ...
p61

p61  

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1. A STE20-like serine/threonine kinase (STK4, kinase responsive to stress 2), very similar to p63 (STK3).2. A catalase, P61, that is an immunodominant antigen from Nocardia brasiliensis.
p21-activated kinases

p21-activated kinases  

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A family of serine/threonine protein kinases of the STE20 group. PAK1 (545 aa) homodimers show transinhibition but dissociate and are activated by GTP-cdc42 or GTP-rac1 and are then able to act on ...
WNK

WNK  

A family of serine/threonine kinases (with no K (lysine) protein kinases) of the STE20 family that have cysteine, not lysine, at a key position in the active site and are activated by hyperosmotic ...
SLK

SLK   Quick reference

A Dictionary of Biomedicine (2 ed.)

Reference type:
Subject Reference
Current Version:
2019

...SLK A microtubule-associated STE20 -like kinase (1235 aa, of the germinal centre subfamily of STE20-like kinases) that is required for focal adhesion turnover and cell migration downstream of the FAK / c-src ...

SPAK

SPAK   Quick reference

A Dictionary of Biomedicine (2 ed.)

Reference type:
Subject Reference
Current Version:
2019

...SPAK A serine/threonine kinase (Ste20/SPS-1-related proline, alanine-rich kinase, 547 aa) that will phosphorylate and activate NKCC1 (Na + -K + -2Cl − cotransporter-1). SPAK and OSR1 (oxidative stress-responsive kinase-1), are activated by WNKs...

p61

p61   Quick reference

A Dictionary of Biomedicine (2 ed.)

Reference type:
Subject Reference
Current Version:
2019

...p61 1. A STE20 -like serine/threonine kinase (STK4, kinase responsive to stress 2), very similar to p63 (STK3). 2. A catalase, P61, that is an immunodominant antigen from Nocardia brasiliensis ....

germinal centre

germinal centre   Quick reference

A Dictionary of Biomedicine (2 ed.)

Reference type:
Subject Reference
Current Version:
2019

...generated in the germinal centres. Germinal centre kinase (mitogen-activated protein kinase kinase kinase kinase, MAP4K2, EC 2.7.11.1, 820 aa) is a STE20-like serine/threonine kinase that is activated by TNF α ‎, activates the SAPK pathway, and will inactivate CLH-3 chloride channel. The germinal centre kinases (GCKs) are a subfamily of STE20-like kinases that include MINK1 , Traf2-, and Nck-interacting kinase (TNIK), SOK1 . Germinal centre kinase-like kinase (HGK, hepatocyte progenitor kinase-like kinase, MAP4K4, 1239 aa) activates JNK and is upstream...

SOK1

SOK1   Quick reference

A Dictionary of Biomedicine (2 ed.)

Reference type:
Subject Reference
Current Version:
2019

...SOK1 A Ste20 protein kinase of the germinal centre kinase ( GCK ) family that is activated by oxidant stress and chemical anoxia, a cell culture model of ischaemia. It is localized in the Golgi apparatus, where it functions in a signalling pathway required for cell migration and...

p21-activated kinases

p21-activated kinases   Quick reference

A Dictionary of Biomedicine (2 ed.)

Reference type:
Subject Reference
Current Version:
2019

...p21-activated kinases ( p21-associated kinases ) A family of serine/threonine protein kinases of the STE20 group. PAK1 (545 aa) homodimers show transinhibition but dissociate and are activated by GTP-cdc42 or GTP-rac1 and are then able to act on various targets. PAK1 binds to the SH3 domains of phospholipase C γ ‎ and of Nck , and promotes the disassembly of stress fibres and focal adhesions. PAK2 (507 aa) can be activated by rac or cdc42 and stimulates cell survival, but a caspase -generated constitutively active catalytic fragment induces an...

WNKs

WNKs   Quick reference

A Dictionary of Biomedicine (2 ed.)

Reference type:
Subject Reference
Current Version:
2019

...WNKs A family of serine/threonine kinases (with no K (lysine) protein kinases) of the STE20 family that have cysteine, not lysine, at a key position in the active site and are activated by hyperosmotic stress. WNKs in turn activate SPAK and OSR1 and defects can cause pseudohypoaldosteronism . Human WNK-1 (1246 aa) is expressed in most tissues, but particularly in polarized epithelia involved in chloride ion transport. WNK2 (2126 aa) is widely expressed, but its function is unclear. WNK3 (1800 aa) regulates transport mediated by both the Na-K-2Cl...

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