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Peutz–Jeghers syndrome

A hereditary disorder in which the presence of multiple polyps in the lining of the small intestine (intestinal polyposis) is associated with pigmented areas (similar to freckles) around ...

Peutz-Jeghers syndrome

Peutz-Jeghers syndrome n.   Quick reference

A Dictionary of Nursing (7 ed.)

Reference type:
Subject Reference
Current Version:
2017
Subject:
Medicine and health
Length:
66 words

...Peutz-Jeghers syndrome [puuts- yeg -erz] n. a hereditary disorder in which the presence of multiple polyps in the lining of the small intestine (intestinal polyposis) is associated with pigmented areas (similar to freckles) around the lips, on the inside of the mouth, and on the palms and soles. [ J. L. A. Peutz ( 1886–1957 ), Dutch physician; H. J. Jeghers ( 1904–90 ), US...

Peutz–Jeghers syndrome

Peutz–Jeghers syndrome   Quick reference

A Dictionary of Dentistry (2 ed.)

Reference type:
Subject Reference
Current Version:
2020
Subject:
Medicine and health, Dentistry
Length:
63 words

...–Jeghers syndrome [ J. L. A. Peutz ( 1886–1957 ), Dutch physician; H. J. Jeghers ( 1904–90 ), US physician] A hereditary disorder characterized by polyps of the small intestine and purple or black hamartomatous freckles (melanin spots) around the lips and on the oral mucous membrane; the spots commonly disappear during the teenage period. Approximately half of those affected develop malignant ...

Peutz–Jeghers syndrome

Peutz–Jeghers syndrome   Quick reference

A Dictionary of Biomedicine (2 ed.)

Reference type:
Subject Reference
Current Version:
2019

...PeutzJeghers syndrome An autosomal dominant disorder caused by mutation in the serine/threonine kinase 11 gene ( LKB1 ), in which benign polyps develop in the gastrointestinal tract and there is a fifteen-fold increased risk of developing malignant tumours in other tissues....

Peutz–Jeghers syndrome

Peutz–Jeghers syndrome   Quick reference

Concise Medical Dictionary (10 ed.)

Reference type:
Subject Reference
Current Version:
2020
Subject:
Medicine and health, Clinical Medicine
Length:
101 words

...–Jeghers syndrome a hereditary disorder in which the presence of multiple polyps in the lining of the small intestine (intestinal polyposis ) is associated with pigmented areas (similar to freckles) around the lips, on the inside of the mouth, and on the palms and soles. The polyps can also occur in the colon and stomach. They may bleed, resulting in anaemia, or may cause obstruction of the bowel. Half of the patients develop malignant tumours (not necessarily of the bowel). [ J. L. A. Peutz ( 1886–1957 ), Dutch physician ; H. J. Jeghers (...

Peutz–Jeghers syndrome

Peutz–Jeghers syndrome  

Reference type:
Overview Page
A hereditary disorder in which the presence of multiple polyps in the lining of the small intestine (intestinal polyposis) is associated with pigmented areas (similar to freckles) around the lips, on ...
LKB1

LKB1  

Reference type:
Overview Page
A kinase (serine/threonine kinase 11, STK11, 433 aa) mutated in Peutz–Jeghers syndrome that interacts with p53; deficiency is associated with defective apoptosis.
gastric cancer

gastric cancer  

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Overview Page
Carcinoma of the stomach, probably the second most common carcinoma. Several genes may be associated with an increased risk of gastric cancer and there are various inherited cancer predisposition ...
melanin pigmentation

melanin pigmentation  

A change in the amount of melanin produced. It may be developmental (see melanocytic naevus; Peutz-Jeghers syndrome; café au lait spots) or acquired as the result of systemic disease (see Addison's ...
polyposis

polyposis  

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Overview Page
n. a condition in which numerous polyps form in an organ or tissue. Familial adenomatous polyposis (FAP) is a hereditary disease (caused by a defective dominant gene) in which multiple adenomas ...
polyp

polyp  

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Overview Page
1. A growth, usually benign, that projects from a mucous membrane and resembles (vaguely) (2).2. The sessile stage of the life cycle of some coelenterates (e.g. Hydra), a cylindrical body attached to ...
LKB1

LKB1   Quick reference

A Dictionary of Biomedicine (2 ed.)

Reference type:
Subject Reference
Current Version:
2019

...LKB1 A kinase (serine/threonine kinase 11, STK11, 433 aa) mutated in PeutzJeghers syndrome that interacts with p53 ; deficiency is associated with defective...

gastric cancer

gastric cancer   Quick reference

A Dictionary of Biomedicine (2 ed.)

Reference type:
Subject Reference
Current Version:
2019

...of the stomach, probably the second most common carcinoma. Several genes may be associated with an increased risk of gastric cancer and there are various inherited cancer predisposition syndromes, including hereditary nonpolyposis colon cancer ( see GTBP ); familial adenomatous polyposis ( polyposis coli ); PeutzJeghers syndrome ; Cowden’s disease ; Li–Fraumeni syndrome ). One form of familial gastric cancer is caused by germline mutations in the E-cadherin gene, others by somatic mutations in a range of genes. Only ~10% of cases have a clear hereditable...

polyp

polyp n.   Quick reference

A Dictionary of Nursing (7 ed.)

Reference type:
Subject Reference
Current Version:
2017
Subject:
Medicine and health
Length:
95 words

...Polyps are usually removed endoscopically ( see polypectomy ). juvenile p. a polyp that occurs in the intestine (usually colon or rectum) of infants or young people; sometimes they are multiple ( see polyposis ). Most juvenile polyps are benign. See also Peutz-Jeghers syndrome...

polyposis

polyposis n.   Quick reference

A Dictionary of Nursing (7 ed.)

Reference type:
Subject Reference
Current Version:
2017
Subject:
Medicine and health
Length:
70 words

...hereditary disease in which multiple adenomas develop in the gastrointestinal tract, usually the colon or rectum, at an early age. As these polyps almost invariably become malignant, patients are usually advised to undergo total removal of the affected bowel. See also Peutz-Jeghers syndrome . Compare pseudopolyposis...

polyposis

polyposis n.   Quick reference

Concise Medical Dictionary (10 ed.)

Reference type:
Subject Reference
Current Version:
2020
Subject:
Medicine and health, Clinical Medicine
Length:
79 words

...defective dominant gene) in which multiple adenomas develop in the intestine, usually the large bowel or rectum, at an early age. As these polyps almost invariably become malignant, patients are usually advised to undergo total removal of the affected bowel. See also Peutz-Jeghers syndrome . Compare hereditary nonpolyposis colorectal cancer ; pseudopolyposis...

melanin pigmentation

melanin pigmentation   Quick reference

A Dictionary of Dentistry (2 ed.)

Reference type:
Subject Reference
Current Version:
2020
Subject:
Medicine and health, Dentistry
Length:
72 words

...pigmentation A change in the amount of melanin produced. It may be developmental ( see melanocytic naevus ; Peutz-Jeghers syndrome ; café au lait spots ) or acquired as the result of systemic disease ( see Addison’s disease ), malignancy ( see melanoma ), or a simple local disorder ( see melanotic macule ). Pigmentation of the soft palate is associated with smoking and bronchiogenic carcinoma . Certain drugs may also cause oral...

polyp

polyp n.   Quick reference

Concise Medical Dictionary (10 ed.)

Reference type:
Subject Reference
Current Version:
2020
Subject:
Medicine and health, Clinical Medicine
Length:
177 words

...polyps occur in the intestine (usually colon or rectum) of infants or young people; sometimes they are multiple ( juvenile polyposis ). In the latter form there is a risk of malignant change (25% of cases) but most juvenile polyps are benign ( see also polyposis ; Peutz-Jeghers syndrome ). Polyps are usually removed endoscopically ( see polypectomy ); polyps that are large, difficult to remove endoscopically, or malignant require...

Inherited medical conditions

Inherited medical conditions   Quick reference

Concise Medical Dictionary (10 ed.)

Reference type:
Subject Reference
Current Version:
2020
Subject:
Medicine and health, Clinical Medicine
Length:
253 words

...hyperthermia Marfan’s syndrome maturity-onset diabetes of the young (MODY) Mowat-Wilson syndrome multiple endocrine neoplasia (MEN) types 1 and 2 neurofibromatosis Noonan’s syndrome Osler-Rendu-Weber syndrome osteogenesis imperfecta (types I–VI) osteopetrosis (mild form) otosclerosis (some forms) Peutz-Jeghers syndrome Pfeiffer syndrome protein C deficiency retinitis pigmentosa (some mild forms) retinoblastoma (some forms) Treacher Collins syndrome tuberous sclerosis von Hippel-Lindau disease von Willebrand’s disease Waardenburg’s syndrome Autosomal recessive...

freckles

freckles   Reference library

The Oxford Companion to the Body

Reference type:
Subject Reference
Current Version:
2003
Subject:
Science and technology, Life Sciences
Length:
610 words

...to spots produced by increased melanin in some of the fair-skinned. Various types of mottling or spotting of bodily surfaces are sometimes called freckling, including spotting caused by several diseases. The presence of brown ‘freckles’ on the lips can indicate Peutz-Jegher's syndrome , which is characterized by intestinal polyps, while chronic liver disease can produce ‘spider naevi’ on the skin surface. The use of ‘freckle’ extends beyond references to the skin, covering descriptions of a range of small spots. In Shakespeare's A Midsummer Night's...

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