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Overview

CREB

The abbreviation for cyclic AMP response element binding proteins. These proteins are required for the consolidation of short-term memory into long-term memory. Genes encoding CREBs have ...

CREB

CREB   Quick reference

A Dictionary of Biomedicine (2 ed.)

Reference type:
Subject Reference
Current Version:
2019

...CREB A basic leucine zipper (bZip) transcription factor (cAMP response element binding factor, CREB-1, 341 aa) that is activated when it is phosphorylated by cAMP-dependent protein kinase ( PKA ). Phosphorylation allows DNA binding and interaction with MECT1 and with CREB binding protein (EC 2.3.1.48, 2442 aa), a transcriptional coactivator. Several other forms of CREB are known (CREB3, CREB5) and various CREB-regulated transcriptional coactivators. A chromosomal aberration involving CREB1 is associated with angiomatoid fibrous histiocytoma...

CREB

CREB abbrev.   Quick reference

A Dictionary of Psychology (4 ed.)

Reference type:
Subject Reference
Current Version:
2015

... abbrev. Cyclic AMP response element binding protein, a compound present in neurons . When activated by cyclic AMP it initiates the consolidation of long-term memories by switching on genes whose protein production strengthens specific synapses . A drug that enhances CREB production or function might enhance memory and function as a smart drug . See also mem 1414...

CREB protein

CREB protein   Reference library

Oxford Dictionary of Biochemistry and Molecular Biology (2 ed.)

Reference type:
Subject Reference
Current Version:
2008
Subject:
Science and technology, Life Sciences
Length:
79 words

... protein abbr. for cyclic AMP response element binding protein; a protein that, following phosphorylation by cyclic AMP‐dependent protein kinase on a single serine residue, binds to the cyclic AMP response element ( CRE ). This then stimulates transcription of genes controlled by regulatory regions that contain the CRE. It regulates genes (responsive to nerve growth factor) for ion channels, for enzymes of neurotransmitter synthesis, and for cytoskeletal components, and is involved in learning, memory, and drug addiction. See CBP...

CREB

CREB  

Reference type:
Overview Page
A basic leucine zipper (bZip) transcription factor (cAMP response element binding factor, CREB-1, 341 aa) that is activated when it is phosphorylated by cAMP-dependent protein kinase (PKA). ...
CREB

CREB  

The abbreviation for cyclic AMP response element binding proteins. These proteins are required for the consolidation of short-term memory into long-term memory. Genes encoding CREBs have been cloned ...
Crebs

Crebs   Reference library

Dictionary of American Family Names (2 ed.)

Reference type:
Subject Reference
Current Version:
2022
Subject:
Names studies
Length:
10 words

... US frequency (2010): 250 Americanized form of German Krebs...

CREBs

CREBs   Quick reference

A Dictionary of Genetics (8 ed.)

Reference type:
Subject Reference
Current Version:
2014
Subject:
Science and technology, Life Sciences
Length:
78 words

... The abbreviation for c yclic AMP r esponse e lement b inding proteins. These proteins are required for the consolidation of short-term memory into long-term memory. Genes encoding CREBs have been cloned in Drosophila . One of these genes, dCREB2 , encodes a protein, dCREBa, that activates transcription of genes that enhance the ability of the fly to consolidate short-term memory into long-term memory. The isoform dCREBb inhibits this process. See Appendix C , 1982, Kandel and Schwartz; 1994, Tully et al ., cyclic...

crebs

crebs adj. (W.I.)   Reference library

Green's Dictionary of Slang

Reference type:
Subject Reference
Current Version:
2011
Subject:
Language reference
Length:
18 words

... adj. [ety. unknown] ( W.I. ) low-life, despicable. 1995 Francis-Jackson Official Dancehall Dict. 12: Crebs ( off .) low...

CBP

CBP  

abbr. for CREB protein‐binding protein; a large nuclear multifunctional protein expressed in most vertebrate cell types that binds to a wide variety of transcription factors and has intrinsic histone ...
smart drug

smart drug  

A non-technical name for any drug believed to have nootropic effects or to enhance cognitive ability or performance. Also called a cognitive enhancer. See caffeine, CREB, deprenyl, ginkgo, ginseng, ...
spaced training

spaced training  

Referring to experiments on memory during which repeated training sessions are given with short rest intervals between the sessions. The term massed training refers to repeated training sessions with ...
MEM 1414

MEM 1414  

Memory 1414, a smart drug developed in the 1990s that inhibits phosphodiesterase type 5 and thereby reduces the metabolization of cyclic AMP and increases the prevalence of CREB in neurons in the ...
CRE

CRE  

abbr. for cyclic AMP response element; a sequence,GTGACGT[A/G][A/G], that is present in many viral and cellular promoters. When it binds CREB protein, transcription of the genes regulated by such a ...
basic leucine zipper proteins

basic leucine zipper proteins  

Reference type:
Overview Page
A family of transcription factors (bZIP proteins) with a basic DNA-binding domain and a leucine zipper region involved in forming homo- or heterodimers. Examples include AP-1, ATF, and CREB.
angiomatoid fibrous histiocytoma

angiomatoid fibrous histiocytoma  

Reference type:
Overview Page
A variant of malignant fibrous histiocytoma that typically occurs in children and adolescents. It is associated with somatic fusions of several genes, including ATF1 (cAMP-dependent transcription ...
CREM

CREM  

Reference type:
Overview Page
One of a large family of transcriptional activators (cAMP response element modulators, ATF/CREM/CREB family).
Rubinstein–Taybi syndrome

Rubinstein–Taybi syndrome  

Reference type:
Overview Page
A syndrome characterized by mental retardation, broad thumbs and toes, and facial abnormalities that can be caused by mutation in the gene encoding CREB-binding protein or in the EP300 gene (see ...
protein kinase IV

protein kinase IV  

Reference type:
Overview Page
A multifunctional calcium/calmodulin-dependent serine/threonine protein kinase (brain CaM kinase IV, 503 aa) implicated in transcriptional regulation in lymphocytes, neurons, and male germ cells by ...
bZIP

bZIP  

abbr. for basic zipper; a characteristic feature of a family of proteins that possess a basic region (b) and a leucine zipper domain (ZIP). The basic region harbours a DNA‐contact ...

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