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interleukin-20

(IL-20) One of the IL-10 family of cytokines, produced by monocytes and keratinocytes, and an autocrine factor for keratinocytes. The receptor is up-regulated dramatically in ...

interleukin-20

interleukin-20   Quick reference

A Dictionary of Biomedicine (2 ed.)

Reference type:
Subject Reference
Current Version:
2019

...interleukin-20 ( IL-20 ) One of the IL-10 family of cytokines, produced by monocytes and keratinocytes, and an autocrine factor for keratinocytes. The receptor is up-regulated dramatically in psoriatic skin....

lymphokine

lymphokine  

n. a substance produced by lymphocytes that has effects on other cells involved in the immune system (see cytokines). An example is interleukin 2 (IL-2).
cytokines

cytokines   Quick reference

A Dictionary of Genetics (8 ed.)

Reference type:
Subject Reference
Current Version:
2014
Subject:
Science and technology, Life Sciences
Length:
57 words

...a group of small proteins (5–20 kilodaltons) involved primarily in communication between cells of the immune system. Unlike hormones of the endocrine system, which can exert their effects over long distances, cytokines usually act locally on nearby cells. The term includes interleukins, interferons, lymphokines, and tumor necrosis factors ( all of which see ). Compare with autocrine...

chemokine

chemokine   Reference library

Oxford Dictionary of Biochemistry and Molecular Biology (2 ed.)

Reference type:
Subject Reference
Current Version:
2008
Subject:
Science and technology, Life Sciences
Length:
118 words

... or intercrine any of a subgroup of cytokines acting primarily as chemotactic agents that cause accumulation of leukocytes into tissues. They are secreted in response to inflammatory cytokines (e.g. interleukin 1, THFα), bacterial products, or viral infection. They are basic polypeptides (8–10 kDa), more than 40 of which are known and showing 20–70% homology. Subdivison into four families is on the basis of the number and relative position of their cysteine residues. More than a dozen G‐protein‐associated cytokine receptors activate phospholipase C....

Crohn's disease

Crohn's disease   Reference library

Oxford Dictionary of Biochemistry and Molecular Biology (2 ed.)

Reference type:
Subject Reference
Current Version:
2008
Subject:
Science and technology, Life Sciences
Length:
112 words

...enteritis a chronic inflammatory disease that usually affects the ileum and colon, and frequently runs in families. The inflamed lesions are rich in the inflammatory cytokines, particularly interleukins 1, 6, and 12 and tumour necrosis factor α. Homozygosity for a mutation in a gene (called NOD2 ) on chromosome 16 increases the risk of the disease by a factor of 20–40. NOD2 encodes an intracellular protein that contains 2 caspase‐recruitment domains, a nucleotide‐binding domain, and 10 leucine‐rich sequence repeats in the C‐terminal region. It may have a...

interleukin-19

interleukin-19   Quick reference

A Dictionary of Biomedicine (2 ed.)

Reference type:
Subject Reference
Current Version:
2019

...interleukin-19 ( IL-19 ) A cytokine of the IL-10 family (melanoma differentiation associated protein-like protein, 177 aa), produced by activated monocytes and B cells; induces IL-6 and TNF α ‎ production by monocytes and the production of IL-4, IL-5, IL-10, and IL-13 by activated T-cells; shares its receptor with IL-20 and...

interleukin-25

interleukin-25   Quick reference

A Dictionary of Biomedicine (2 ed.)

Reference type:
Subject Reference
Current Version:
2019

...interleukin-25 ( IL-25 ) A member of the IL-17 family of immunoregulatory cytokines (IL-17E; SF20, a homodimer of 177 aa subunits), produced by Th2 cells. It has a role in allergic inflammation by up-regulating IgG and IgE production, eosinophil levels, and inflammatory responses, through induction of IL-4, IL-5, and...

cytokines

cytokines   Quick reference

A Dictionary of Biomedicine (2 ed.)

Reference type:
Subject Reference
Current Version:
2019

...cytokines A rather loose category of small proteins (~5–20 kDa) that are released by cells and that affect the behaviour of other cells. Normally taken to include interleukins , lymphokines, chemokines and several related signalling molecules such as tumour necrosis factor and interferons but not hormones or growth factors except perhaps transforming growth factor β ‎ (TGF β ‎). http://www.copewithcytokines.de/cope.cgi A very valuable encylopaedia of cytokines and cells (22 600 entries), created, developed, and maintained by Prof. Dr H...

interleukin-10

interleukin-10   Quick reference

A Dictionary of Biomedicine (2 ed.)

Reference type:
Subject Reference
Current Version:
2019

...interleukin-10 ( IL-10 ) A cytokine (cytokine synthesis inhibiting factor, CSIF, TGIF, a homodimer of 160 aa subunits) produced by Th2 cells, some B cells, and LPS-activated monocytes. IL-10 regulates cytokine production by a range of other cells and is an inhibitor of immune responses. Individuals show marked variation in IL-10 secretion in response to LPS and the variation has a strong genetic component. The IL-10 family (IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, IL-28, and IL-29) is highly pleiotropic and although there are shared receptors and...

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