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bZIP
abbr. for basic zipper; a characteristic feature of a family of proteins that possess a basic region (b) and a leucine zipper domain (ZIP). The basic region harbours a DNA‐contact ...

CBP
abbr. for CREB protein‐binding protein; a large nuclear multifunctional protein expressed in most vertebrate cell types that binds to a wide variety of transcription factors and has intrinsic histone ...

CRE
abbr. for cyclic AMP response element; a sequence,GTGACGT[A/G][A/G], that is present in many viral and cellular promoters. When it binds CREB protein, transcription of the genes regulated by such a ...

cyclic AMP
A derivative of ATP that is widespread in cells as a second messenger in many biochemical reactions induced by hormones. Binding of the hormone to its receptor on the cell surface activates G ...

MEM 1414
Memory 1414, a smart drug developed in the 1990s that inhibits phosphodiesterase type 5 and thereby reduces the metabolization of cyclic AMP and increases the prevalence of CREB in neurons in the ...

smart drug
A non-technical name for any drug believed to have nootropic effects or to enhance cognitive ability or performance. Also called a cognitive enhancer. See caffeine, CREB, deprenyl, ginkgo, ginseng, ...

spaced training
Referring to experiments on memory during which repeated training sessions are given with short rest intervals between the sessions. The term massed training refers to repeated training sessions with ...

T antigen
A “tumor” antigen found in the nuclei of cells infected or transformed by certain oncogenic viruses such as polyoma. The antigen is thought to be a protein coded for by a virus cistron.
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