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APC

APC  

The human gene for adenomatous polyposis coli protein. The gene is a tumour suppressor, and mutations are associated with familial adenomatous polyposis, Gardner's syndrome, etc. and contribute to ...
casein kinases

casein kinases  

A group of kinases that preferentially phosphorylate acidic proteins such as caseins but can phosphorylate a large number of proteins. Casein kinase 1 (EC 2.7.11.1, multiple isoforms, ~415 aa) ...
patched

patched  

The human homologue of the Drosophila gene patched. PTCH1 encodes a transmembrane protein with homology to bacterial proton-driven transmembrane molecular transporters and represses genes encoding ...
ryk

ryk  

An atypical receptor protein tyrosine kinase that functions as a coreceptor along with Frizzled for Wnt ligands and binds to dishevelled, through which it activates the canonical Wnt pathway.
WIF-1

WIF-1  

abbr. for Wnt‐inhibitory factor‐1. See Wnt.
wingless

wingless  

A gene in Drosophila melanogaster that encodes a protein in the WNT family, probably a growth factor that acts on neighbouring cells to regulate the engrailed gene. A homologue is present in the ...
Wnt inhibitory factor 1

Wnt inhibitory factor 1  

1 abbr.: WIF‐1; a secreted protein that contains an N‐terminal WIF domain (≈150 amino acids), which binds and inhibits Wnt proteins; five EGF‐like repeats; and a short hydrophilic domain in ...

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