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APC
The human gene for adenomatous polyposis coli protein. The gene is a tumour suppressor, and mutations are associated with familial adenomatous polyposis, Gardner's syndrome, etc. and contribute to ...
casein kinases
A group of kinases that preferentially phosphorylate acidic proteins such as caseins but can phosphorylate a large number of proteins. Casein kinase 1 (EC 2.7.11.1, multiple isoforms, ~415 aa) ...
cellular signal transduction
The pathways through which cells receive external signals and transmit, amplify, and direct them internally. The pathway begins with cell-surface receptors (q.v.) and may end in the cell nucleus with ...
patched
The human homologue of the Drosophila gene patched. PTCH1 encodes a transmembrane protein with homology to bacterial proton-driven transmembrane molecular transporters and represses genes encoding ...
ryk
An atypical receptor protein tyrosine kinase that functions as a coreceptor along with Frizzled for Wnt ligands and binds to dishevelled, through which it activates the canonical Wnt pathway.
wingless
A gene in Drosophila melanogaster that encodes a protein in the WNT family, probably a growth factor that acts on neighbouring cells to regulate the engrailed gene. A homologue is present in the ...
Wnt Reference library
Oxford Dictionary of Biochemistry and Molecular Biology (2 ed.)
abbr. for (Drosophila) Wingless/Int‐1; any of a family of secreted signalling glycoproteins found throughout the animal kingdom. They
WNT family Reference library
Oxford Dictionary of Biochemistry and Molecular Biology (2 ed.)
a family of secreted glycoproteins (e.g. WNT‐2 from human and mouse) that are signalling molecules in tissue development. They act
Wnt inhibitory factor 1
1 abbr.: WIF‐1; a secreted protein that contains an N‐terminal WIF domain (≈150 amino acids), which binds and inhibits Wnt proteins; five EGF‐like repeats; and a short hydrophilic domain in ...
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