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date: 20 June 2025

No-Observed-Adverse-Effect Level (NOAEL) 

Source:
A Dictionary of Epidemiology
Author(s):

Miquel Porta

The highest dose at which no adverse health effects are detected in an animal population. A NOAEL-SF is a no-observed-effects level with an added safety factor for human exposures; it is used in setting human safety standards. In practice, the safety factor added is commonly two or more orders of magnitude (i.e., a hundredfold or a thousandfold greater than the NOAEL).... ...

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