equipoise n.
a state of genuine and substantial uncertainty as to which of two or more courses of action will be best for a patient. Equipoise is an important ethical principle in research, specifically in the design of clinical trials. It is generally held that the random allocation of patients to one or other arm of a trial is ethically acceptable only where there is a genuine uncertainty (equipoise) as to which treatment will most benefit trial participants. Knowingly to assign an individual to inferior or ineffective treatment (such as a placebo) would offend against the principle that his or her ... ...
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