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date: 06 August 2020

Abelson leukaemia virus 

A Dictionary of Biomedicine

John Lackie

, Brian NationBrian Nation

A replication-defective murine leukaemia virus (A-MuLV), a retrovirus, that requires coinfection of cells with a ‘helper’ virus to proliferate and to cause a rapidly progressive lymphosarcoma (the Moloney murine leukaemia virus is often used). The oncogenic effects are due to its acquisition of c-abl, a nonreceptor tyrosine kinase, that has a G-actin binding site and an independent F-actin binding site.... ...

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