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date: 16 December 2019

A Review and Reappraisal of the Default Network in Normal Aging and Dementia 

The Oxford Encyclopedia of Psychology and Aging
Jessica R. Andrews-HannaJessica R. Andrews-Hanna, Matthew D. GrilliMatthew D. Grilli, Muireann IrishMuireann Irish

The brain’s default network (DN)—a distributed network of integrated neural regions—has been implicated in a range of internally guided cognitive processes. Many of the processes supported by the DN are altered in normal aging and are subject to decline in neurodegenerative diseases that directly disrupt DN integrity, such as Alzheimer’s disease (AD) and frontotemporal dementia (FTD). To date, research on the DN in aging paints a largely pessimistic picture, with loss of functional DN integrity posited to drive both alterations in healthy aging and aberrations in pathological aging. In this article, the standard view of the DN in aging is referred to as the ... ...

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