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double-blind study

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A randomized controlled trial in which the allocation of study subjects to receive or not receive the regimen being tested is concealed from both the subjects and from the investigator(s) conducting the trial. The aim is to reduce the effects of bias, such as the placebo effect and the halo effect, as well as selection bias and observer bias. Some people consider the use of the word “blind” offensive in this context, and to respect their sensibility the term “double-masked study” is proposed as an alternative.

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