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Barker hypothesis

Syn: thrifty phenotype hypothesis. A hypothesis proposed in 1990 by the British epidemiologist David Barker (b. 1939) that intrauterine growth retardation, low birth weight, and premature ...

Barker hypothesis

Barker hypothesis   Quick reference

A Dictionary of Public Health

Reference type:
Subject Reference
Current Version:
2007

... hypothesis Syn: thrifty phenotype hypothesis . A hypothesis proposed in 1990 by the British epidemiologist David Barker ( 1938–2013 ) that intrauterine growth retardation, low birth weight, and premature birth have a causal relationship to the origins of hypertension, coronary heart disease, and non-insulin-dependent diabetes, in middle age. Barker's hypothesis derived from a historical cohort study that revealed a significant association between the occurrence of hypertension and coronary heart disease in middle age and premature birth or low birth...

Barker hypothesis

Barker hypothesis  

Syn: thrifty phenotype hypothesis. A hypothesis proposed in 1990 by the British epidemiologist David Barker (b. 1939) that intrauterine growth retardation, low birth weight, and premature birth have ...
A Midsummer Night’s Dream

A Midsummer Night’s Dream   Reference library

Michael Dobson and Anthony Davies

The Oxford Companion to Shakespeare (2 ed.)

Reference type:
Subject Reference
Current Version:
2015
Subject:
Literature, Shakespeare studies and criticism, Performing arts, Theatre
Length:
3,220 words
Publisher:
Oxford University Press
Illustration(s):
1

...included an 8-year-old Ellen Terry entering as Robin Goodfellow on a pop-up mushroom. This tradition of spectacle peaked in Beerbohm Tree ’s production ( 1900 ): his wood featured real live rabbits. More indicative of 20th-century Dreams to come was Harley Granville-Barker ’s controversial 1914 production at the Savoy, with its gilded, other-worldly, puppet-like fairies. Since then the play has been both immensely popular (one of the most frequently revived in the canon, especially in outdoor venues: it appeared every year at the Open Air...

programming, metabolic

programming, metabolic  

Reference type:
Overview Page
The idea that nutrition in utero (and hence maternal nutrition) and early post-natal life leads to epigenetic programming of metabolism, and predisposes to chronic disease in later life. Sometimes ...
intrauterine growth retardation

intrauterine growth retardation  

A condition in which fetal development proceeds more slowly than normal, developmental milestones are reached later than expected, and prospects of delivery of a healthy full-term infant are ...
life course

life course  

The natural history of human life. A term for conditions that evolve over a large part or all of the life span from infancy, or even from conception, through adolescence, adult life, and senescence, ...
non-insulin-dependent diabetes

non-insulin-dependent diabetes  

(NIDDM)Syn: adult-onset diabetes, type 2 diabetes. This form of adult-onset diabetes is commonly associated with obesity and usually responds well to a strict dietary regimen; it does not usually ...
programming, metabolic

programming, metabolic   Quick reference

A Dictionary of Food and Nutrition (4 ed.)

Reference type:
Subject Reference
Current Version:
2014

...metabolic The idea that nutrition in utero (and hence maternal nutrition) and early post-natal life leads to epigenetic programming of metabolism, and predisposes to chronic disease in later life. Sometimes known as the Barker hypothesis, since it was first enunciated by David Barker ( 1938–2013 ). See also epigenetics...

Thrifty Phenotype Hypothesis

Thrifty Phenotype Hypothesis   Quick reference

A Dictionary of Epidemiology (6 ed.)

Reference type:
Subject Reference
Current Version:
2016

...Thrifty Phenotype Hypothesis The hypothesis proposed by Nick Hales and David Barker in 1992, that an undernourished fetus becomes thrifty. 771 Fetal undernutrition leads to impaired development of the pancreas, liver, and other tissues (e.g., muscle), leading to low insulin secretion and insulin resistance, which maintains high levels of sugar in the fetal bloodstream to preserve brain development, but may trade off muscle development. Once adopted, this thrifty behavior becomes permanent and, combined with adiposity in later life, leads to type 2...

life course

life course   Quick reference

A Dictionary of Public Health

Reference type:
Subject Reference
Current Version:
2007

...in early adult life, sometimes in middle age, but generally progressing throughout life as a person grows older. The term is recognition of the fact that the natural history of many chronic diseases and the natural life span of humans are intertwined. See, for example, Barker hypothesis...

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